RENAL ANOMALIES IN MARDEN-WALKER SYNDROME - A CLUE FOR PRENATAL-DIAGNOSIS

Marden-Walker syndrome is an autosomal-recessive disorder characterize d by psychomotor retardation, blepharophimosis, joint contractures, ar achnodactyly, failure to thrive, and, infrequently, renal anomalies. W e report on the prenatal diagnosis of Marden-Walker syndrome in a fetu s which had had a previously affected sib with this syndrome. The ultr asonic findings indicative of the diagnosis in this fetus were intraut erine growth retardation and renal cystic disease. We emphasize the im portance of renal anomalies which, when present in combination with ot her ultrasound evidence of this syndrome, should be used as a clue for the diagnosis of Marden-Walker syndrome. (C) 1995 Wiley-Liss, Inc.