PATENT DUCTUS-ARTERIOSUS - CLINICAL RELEVANCE OF PROSTAGLANDINS AND PROSTAGLANDIN INHIBITORS IN PDA PATHOPHYSIOLOGY AND TREATMENT

This article presents a comprehensive review of the patent ductus arte riosus which so often affects the premature neonate. Included are a di scussion of the unique anatomy and physiology of the ductus, a review of the mechanisms involved in normal closure, and factors leading to p ersistent patency. Various therapeutic options also are discussed, inc luding some new and innovative approaches.