POSSIBLE INVOLVEMENT OF PERIPHERAL-TYPE BENZODIAZEPINE RECEPTORS IN ERYTHROID-DIFFERENTIATION OF HUMAN LEUKEMIA-CELL LINE, K562

Authors
NAKAJIMA O HASHIMOTO Y IWASAKI S
Citation
O. Nakajima et al., POSSIBLE INVOLVEMENT OF PERIPHERAL-TYPE BENZODIAZEPINE RECEPTORS IN ERYTHROID-DIFFERENTIATION OF HUMAN LEUKEMIA-CELL LINE, K562, Biological & pharmaceutical bulletin, 18(6), 1995, pp. 903-906
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
18
Issue
6
Year of publication
1995
Pages
903 - 906
Database
ISI
SICI code
0918-6158(1995)18:6<903:PIOPBR>2.0.ZU;2-R
Abstract
Possible involvement of the peripheral-type benzodiazepine receptor (P BR) in hemin/protoporphyrin-induced erythroid differentiation of human leukemia K562 cells was investigated by the use of the ligands, diaze pam and PK11195. Diazepam itself exhibited differentiation-inducing ac tivity on K562 cells. The PBR-specific antagonist, PK11195, dose-depen dently inhibited both diazepam-induced and hemin/protoporphyrin-induce d K562 cell differentiation. The results imply that PBR is involved in the erythroid differentiation of K562 cells.