DESIGN AND USE OF AN APPARATUS FOR MEASURING DIFFUSION THROUGH GLYCEROGELATIN FILMS

The diffusion of ethanol into and through soft gelatin films analogous to capsule shell formulations during the drying process has been inve stigated using a specially designed diffusion cell. Using microcompute r-controlled sampling, it was possible to monitor the diffusion throug h films at regular intervals for periods of 24 h and longer. Films hav ing moisture contents in the range 4.5-42% w/w were investigated. The moisture content of the glycerogelatin soft gelatin capsule shell form ulations has an important influence on the diffusion process; the high er the moisture content, the more rapid the diffusion of ethanol.