TAXUSPINE-D, A NEW TAXANE DITERPENE FROM TAXUS-CUSPIDATA WITH POTENT INHIBITORY ACTIVITY AGAINST CA2-INDUCED DEPOLYMERIZATION OF MICROTUBULES()

Authors
KOBAYASHI J HOSOYAMA H SHIGEMORI H KOISO Y IWASAKI S
Citation
J. Kobayashi et al., TAXUSPINE-D, A NEW TAXANE DITERPENE FROM TAXUS-CUSPIDATA WITH POTENT INHIBITORY ACTIVITY AGAINST CA2-INDUCED DEPOLYMERIZATION OF MICROTUBULES(), Experientia, 51(6), 1995, pp. 592-595
Citations number
12
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Experientia → ACNP
ISSN journal
00144754
Volume
51
Issue
6
Year of publication
1995
Pages
592 - 595
Database
ISI
SICI code
0014-4754(1995)51:6<592:TANTDF>2.0.ZU;2-C
Abstract
A new taxane diterpenoid, taxuspine D (1), possessing an enolacetate m oiety, has been isolated from stems of the Japanese yew Taxus cuspidat a Sieb. et Zucc., and the structure elucidated on the basis of spectro scopic data. Taxuspine D (1) markedly inhibited Ca2+-induced depolymer ization of microtubules.