KINETICS OF PHENOLS IN BODY-FLUID COMPARTMENTS DURING HEMODIALYSIS

On the basis of direct quantification of hemodialysis (HD), the kineti cs of phenols (Ph) were followed in 13 patients on regular HD treatmen t. The average plasma levels of Ph before and after HD were 627 +/- 10 9 mu mol/L and 416 +/- 81 mu mol/L, respectively. The total amount of Ph removed during 5-h HD was 7,481 +/- 1,894 mu mol. For calculation o f the generation rate (G), a new formula has been derived not requirin g knowledge of the corresponding volume of distribution. The G of Ph w as 2.9 +/- 0.7 mu mol/min on average. The mean dialysis clearance (K) of Ph was 48.2 1 10.2 ml/min.