Ms. Promyslov et Ml. Demchuk, INTERRELATIONSHIP BETWEEN THE FUNCTIONAL-STATE OF THE CENTRAL-NERVOUS-SYSTEM AND LIPID-PEROXIDATION LEVEL IN BRAIN FOLLOWING CRANIOCEREBRALTRAUMA, Molecular and chemical neuropathology, 25(1), 1995, pp. 69-80
The interrelationship between the functional state of the CNS and brai
n metabolism was studied in animals following craniocerebral trauma. L
ipid peroxidation and antioxidant activity of rabbit brain were invest
igated a day after craniocerebral trauma. An increase in conjugated di
enes, TEA-reactive products (TBARP), and fluorescent Schiff bases (Sch
B), and a sharp decrease in antioxidant activity in all brain regions
investigated were established. The possibility of regulation of the di
sturbed processes by artificial alteration of the functional state of
the CNS was shown. It was found that the day after stimulation of inju
red brain by amphetamine (phenamin) or piracetam, the values of lipid
peroxidation and antioxidant activity came to the same levels as for c
ontrols. On the contrary, the depression of the CNS by phenobarbital (
luminal) was not accompanied by such positive reactions. The stimulant
s did not possess antioxidant activity in vitro experiments on a model
system. Thus, it was shown that following craniocerebral trauma, the
lipid peroxidation process can be regulated by modification of the fun
ctional state of the CNS alone without special antioxidant therapy.