DISTURBANCE OF MOLECULAR MECHANISMS OF CE LL-ADHESION IN THE LIVER INMICE GENETICALLY PREDISPOSED TO SPONTANEOUS BLASTOMOGENESIS

Macromolecular adhesion factors (MAFs) were obtained from the liver of mice with a genetic predisposition for spontaneous hepatoblastomogene sis (CBA) and of resistant mice (C57B1). The MAFs from the liver of bo th strains are similar in their chemical nature and represent a comple x of phosphoglycopeptides with a molecular mass of 20 - 40 kDa and gly cosaminoglycans. The discovered basic difference in the biological eff ect of MAFs of these strains on the adhesion of hepatocytes appears to be due to disturbances of MAF glycosylation in CBA mice, which cause changes in the spatial-functional organization of the adhesion site in the hepatocytes.