POLYMORPHISM OFF T-SPECIFIC DNA ELEMENTS OF THE PROXIMAL PART OF MUS MOUSE CHROMOSOME-17

To study structural organization and polymorphism of the proximal part of chromosome 17, a hybridization analysis of DNA from mice of differ ent origin was carried out using four t-specific probes. Results of th e analysis allow us to conclude that the DNA element copy number is qu antitatively unstable and differs in distribution in both newly formed recombinant haplotypes and in wild-type chromosome 17. Probe Tu66 was used to study D17Leh66-element organization of Mus abbotti and Mus ho rtulanus mice. Three types of D17Leh66-elements were identified in the genomes of these species. The copy number of each type of DNA element varied in the: genome of each of four studied species. Homologs to t- specific Tu66 and Tu119 probes were found in the genome of Rattus norv egicus rat. The data obtained are discussed with respect to the evolut ion of the proximal part of Mus mouse, chromosome 17.