DISTRIBUTION OF HAPTOGLOBIN TYPES AND THE IR SIGNIFICANCE FOR CHANGESIN BIOCHEMICAL AND IMMUNOLOGICAL PARAMETERS OF PEOPLE IRRADIATED AT SMALL DOSES

Haptoglobin (Hp) polymorphism and its significance for changes in bioc hemical and immunological parameters was analyzed in personnel of a nu clear plant receiving doses of external and internal irradiation close to maximum permissible levels. The distribution of Hp types and frequ encies of alleles Hp in the group of probands asa a whole (1-1-14.1%; 2-1-49.2%; and 2-2-36.7%) and in probands subjected to different types and doses of irradiation (1-1,13.6-16.0%; 2-1,47.8-50.5%; and 2-2:35. 8%-38.2%) did not differ from those expected or from corresponding par ameters of the control group and population. An increase in the freque ncy of allele Hp(1) was observed for persons over 60 years of age. It was found that the levels of uric acid, the activities of acid phospha tase, lactate dehydrogenase, alkaline phosphatase and its isozymes, an d the content of certain lymphocyte classes and immune complexes are i nitially higher in carriers of Hp type 1-1. In these probands, changes in certain parameters related to irradiation were observed less frequ ently. In some cases, opposite changes in immunological parameters wer e observed in persons with different Hp types after internal irradiati on.