THE EFFECT OF LOSHTAK HERBAL PREPARATION ON THE CLASTOGENIC ACTIVITY OF CYCLOPHOSPHAMIDE

The anticlastogenic effect of the herbal preparation Loshtak on rats a nd mice was tested using the same scheme of treatment and doses of the preparation as are employed in medical practice. It was shown that in tragastric administration of Loshtak results in a statistically signif icant. decrease in the clastogenic effect of cyclophosphamide injected 48 h after the end of treatment with Loshtak. High doses of Loshtak d id not induce any increase in the number of micronuclei in mouse bone marrow cells. Possible mechanisms responsible for the anticlastogenic effect of Loshtak are discussed.