FAMILIAL CONGENITAL PERIODIC ALTERNATING NYSTAGMUS WITH PRESUMABLY X-LINKED DOMINANT INHERITANCE

Familial congenital periodic alternating nystagmus (PAN) with presumab ly X-linked dominant inheritance (XLPAN) was observed in the proband a nd her mother. Many relatives had nystagmus by history. A pedigree was constructed with the data provided by the mother. Permission could no t be obtained to contact any other relatives, but incidental medical d ata were obtained from elsewhere. From the pedigree it appeared that a n X-linked dominant pattern of inheritance was most probable. The prob and experienced symptomatic relief of oscillopsia by baclofen therapy (final dose go mg/day) but there was no appreciable change in the nyst agmus intensity (at 120 mg/day).