K. Sato et al., NBQX, A SELECTIVE ANTAGONIST OF THE AMPA RECEPTOR, AFFECTS NEITHER FIELD POTENTIALS NOR LONG-TERM POTENTIATION IN-VIVO, Brain research, 683(2), 1995, pp. 279-282
NBQX ihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline), a selective an
tagonist of AMPA (alpha wamino-3-hydroxy-5-methyl-4-isoxazole propiona
te) receptors, at an anticonvulsant dose of 40 mg/kg (i.p.), was shown
in vivo to have no effects on either the field potentials in the piri
form cortex or those in the dentate gyms of the hippocampus. The same
dose of NBQX also exerted no significant effects on long-term potentia
tion in the hippocampus. These results suggest that the mechanism unde
rlying the anticonvulsant action of NBQX in vivo does not involve a su
ppressive action on physiological synaptic transmission. The possible
clinical usefulness of AMPA receptor antagonists as antiepileptic drug
s is suggested.