In the Northern Hemisphere, sporadic cases of influenza occur during t
he summer, yet summertime outbreaks are rare. From 12 August through 2
September 1993, three influenza outbreaks in Louisiana were investiga
ted using medical-record review, interviews, viral cultures, serology,
and active surveillance for influenza-like illness in Louisiana. Atta
ck rates in the outbreaks were 61% (69/114), 42% (24/57), and 45% (23/
51). Viruses isolated were most closely related to influenza A/ Beijin
g/32/92 (H3N2). The identification of influenza A as the cause of the
first two outbreaks led to the recommendation for amantadine use in th
e third outbreak. Active surveillance did not detect any other outbrea
ks of influenza-like illness during August or September 1993. Out-of-s
eason influenza A outbreaks can therefore occur when little influenza-
like illness is present in a community. Evaluation of outbreaks of acu
te, febrile respiratory illness outside the influenza season should in
clude this possibility, since rapid detection can lead to the timely u
se of amantadine or rimantadine.