Aqueous extracts (AE) of chyrocline flaccida exhibit true antiviral ac
tivity in vitro against different members of the Herpesvirus family (h
erpes simplex virus type 1 and 2, human cytomegalovirus, bovine herpes
virus and lower activity with pseudorabies virus). The extract had no
activity against some RNA (naked and enveloped) viruses and adenovirus
es. The extract was not virucidal but its antiviral index (AI) was suf
ficiently high to justify further analysis. A preliminary characteriza
tion indicates that an early step of viral replication was affected by
the aqueous extract.