GENE-THERAPY MITOCHONDRIAL DISEASES USING HUMAN CYTOPLASTS

Authors
KAGAWA Y HAYASHI JI
Citation
Y. Kagawa et Ji. Hayashi, GENE-THERAPY MITOCHONDRIAL DISEASES USING HUMAN CYTOPLASTS, Gene therapy, 4(1), 1997, pp. 6-10
Citations number
28
Categorie Soggetti
Pharmacology & Pharmacy","Genetics & Heredity",Biology
Journal title
Gene therapy → ACNP
ISSN journal
09697128
Volume
4
Issue
1
Year of publication
1997
Pages
6 - 10
Database
ISI
SICI code
0969-7128(1997)4:1<6:GMDUHC>2.0.ZU;2-X
Abstract
Mitochondrial (mt) DNA is highly susceptible to mutation. A novel appr oach using cytoplasis essential for gene therapy of the diseases cause d by these mutations, because of their non-Mendelian genetics. In this method, mtDNA is transferred into the mutant cells by forming cybrids and can complement the defect correctly and safely.