A retrospective study was performed to examine the results of treatmen
t for cervical lymph node metastases from an unknown primary between 1
978 and 1988. We reviewed 66 patients treated with either surgery and/
or radiotherapy (n = 41), radiation therapy and chemotherapy (n = 11),
combined modality treatment with surgery (n = 8) or with management d
elayed to proven disease (n = 6). The male-to-female ratio was 5.6 to
1, and the median age was 64 years (range, 15-89 years). Intercurrent
death-corrected 5-year survival was 50%. The most important prognostic
factors were M category and involvement of supraclavicular nodes. Pri
mary tumor was eventually discovered in 12 patients during follow-up,
6 of whom received treatment with curative intent. The most common sit
e of primary tumor was found to be the lung (n = 5).