IMPROVEMENT OF DEXAMETHASONE DISSOLUTION RATE FROM SPRAY-DRIED CHITOSAN MICROSPHERES

Chitosans of two different molecular weights are proposed as constitue nts of microparticulate matrices loaded with a water-insoluble drug. D examethasone was chosen as the model drug. The dexamethasone-loaded mi crospheres, prepared by spray drying, were studied with respect to mor phological characteristics, drug content, particle size distributions, thermal behaviour and powder X-ray diffraction characteristics, and i n vitro drug release. A remarkable enhancement of the dissolution rate of dexamethasone was achieved.