PHYSICAL-PROPERTIES AND STABILITY EVALUATION OF SUBMICRON MEFLOQUINE EMULSIONS

Several oil-in-water submicron emulsions with different amounts of emu lsifiers were prepared by ultrasonication and their physico-chemical p roperties examined with the aim of formulating physically stable drug- loaded emulsions. The properties of submicron O/W emulsions prepared b y dispersion of sesame oil solutions of mefloquine and two potential l ipophilic prodrugs in iso-osmotic sorbitol solutions were evaluated be fore and after autoclaving and also after storage. The physical stabil ity of the drug-loaded emulsions upon dilution with salt and dextrose solutions was investigated.