SPECTROPHOTOMETRIC AND SPECTROFLUOROMETRIC DETERMINATION OF CIPROFLOXACIN

Two methods are presented for the analysis of ciprofloxacin. The first method is based on the application of A(max), Delta A, first and seco nd derivative techniques for its determination in bulk powder and tabl et form. The use of absorbency and derivative maxima ratios as purity indices is discussed. The second method is dependent on the fluorescen ce characteristics of ciprofloxacin in acidic solutions. The spectrofl uorimetric method is ten times more sensitive than the spectrophotomet ric one. the accuracy and reproducibility of the methods were shown by the within-day and between-day coefficient of variation (less than 2% ).