Rationale and Objectives. I conducted a study designed to facilitate t
hresholding and reduce volume averaging in three-dimensional (3D) comp
uted tomography (CT) craniofacial modeling. Methods. Three-dimensional
CT reconstructions of orbits from two cadavers and seven clinical cas
es were generated from paired axial and coronal data. A histogram-base
d algorithm that was based on preliminary phantom and craniofacial spe
cimen trials was applied to orbital data to identify volume averaged r
egions of thin bone to be used in conjunction with standard bone thres
holds. Region-of-interest measurement of the orbital floors on the ori
ginal two-dimensional slice data assessed algorithm performance. Resul
ts. In five of the nine cases (55%), configuration of the superimposed
histograms predicted regions of volume averaging. In only one case di
d such a region localize to the orbital floor. In the remaining four c
ases, the air-mucosa interface deep to the orbital floor was identifie
d by the histogram method. Conclusion. Operator-dependent editing rema
ins superior to this histogram-based algorithm in reducing volume aver
aging in 3D craniofacial modeling.