COLLATERAL DEVELOPMENT AND ANGIOGENESIS AFTER MAJOR ARTERY LIGATION DOES NOT ALTER HINDQUARTER VASCULAR REACTIVITY IN CONSCIOUS RABBITS

Authors
Citation
Je. Ward et Ja. Angus, COLLATERAL DEVELOPMENT AND ANGIOGENESIS AFTER MAJOR ARTERY LIGATION DOES NOT ALTER HINDQUARTER VASCULAR REACTIVITY IN CONSCIOUS RABBITS, Journal of cardiovascular pharmacology, 26(1), 1995, pp. 96-106
Citations number
32
Categorie Soggetti
Cardiac & Cardiovascular System","Respiratory System","Pharmacology & Pharmacy
ISSN journal
01602446
Volume
26
Issue
1
Year of publication
1995
Pages
96 - 106
Database
ISI
SICI code
0160-2446(1995)26:1<96:CDAAAM>2.0.ZU;2-0
Abstract
We tested whether vasodilator and vasoconstrictor responses of the hin dquarter vasculature in conscious rabbits were altered 1 day, 2 weeks, and 6 months after bilateral superficial femoral artery ligation (SFA L). With pharmacological autonomic blockade, hindquarter now (Doppler flowmeter) was restored to 84% of control values 1 day postligation (n = 5). Responses to aortic balloon inflation (5-80 s), and intraaortic infusion of norepinephrine, angiotensin II, serotonin, acetylcholine, sodium nitroprusside, and adenosine were similar to pre-SFAL response s. Two weeks post-SFAL, acrylic casts showed an extensive collateral n etwork originating from branches of internal iliac and deep femoral ar teries. Acetylcholine-induced dilatation was attenuated postligation ( n = 7) relative to controls (n = 13). Serotonin caused constriction in two rabbits postligation but dilatation in all others; however respon ses to all other agents tested were similar to controls. Reactive hype remia and vascular reactivity were similar in rabbits 6 months post-SF AL (n = 5) and controls (n = 5). Thus, despite extensive vascular remo deling after SFAL, global hyperemic flow responses of the rabbit hindq uarter vasculature appeared normal. We found only minimal changes in v ascular reactivity to constrictor and dilator stimuli. This model of p eripheral vascular disease does not reflect the clinical syndrome.