Je. Ward et Ja. Angus, COLLATERAL DEVELOPMENT AND ANGIOGENESIS AFTER MAJOR ARTERY LIGATION DOES NOT ALTER HINDQUARTER VASCULAR REACTIVITY IN CONSCIOUS RABBITS, Journal of cardiovascular pharmacology, 26(1), 1995, pp. 96-106
We tested whether vasodilator and vasoconstrictor responses of the hin
dquarter vasculature in conscious rabbits were altered 1 day, 2 weeks,
and 6 months after bilateral superficial femoral artery ligation (SFA
L). With pharmacological autonomic blockade, hindquarter now (Doppler
flowmeter) was restored to 84% of control values 1 day postligation (n
= 5). Responses to aortic balloon inflation (5-80 s), and intraaortic
infusion of norepinephrine, angiotensin II, serotonin, acetylcholine,
sodium nitroprusside, and adenosine were similar to pre-SFAL response
s. Two weeks post-SFAL, acrylic casts showed an extensive collateral n
etwork originating from branches of internal iliac and deep femoral ar
teries. Acetylcholine-induced dilatation was attenuated postligation (
n = 7) relative to controls (n = 13). Serotonin caused constriction in
two rabbits postligation but dilatation in all others; however respon
ses to all other agents tested were similar to controls. Reactive hype
remia and vascular reactivity were similar in rabbits 6 months post-SF
AL (n = 5) and controls (n = 5). Thus, despite extensive vascular remo
deling after SFAL, global hyperemic flow responses of the rabbit hindq
uarter vasculature appeared normal. We found only minimal changes in v
ascular reactivity to constrictor and dilator stimuli. This model of p
eripheral vascular disease does not reflect the clinical syndrome.