ANTI-HUMAN GONADOTROPIN ANTIBODIES GENERATED DURING IN-VITRO FERTILIZATION (IVF)-RELATED CYCLES - EFFECT ON FERTILITY OF RHESUS MACAQUES

Administration of human gonadotropins such as hFSH, hLH, and hCG to rh esus macaques can result in formation of anti-human gonadotropin antib odies. To determine whether the presence of these antibodies interfere s with subsequent fertility, sixteen female rhesus macaques (Macaca mu latta) with known antibody levels were bred with male rhesus macaques. The presence of antibodies did not interfere with conception or maint enance of pregnancy. Furthermore, antibody titers did not increase dur ing gestation or following the resolution of pregnancy.