DIPYRONE AND DICLOFENAC DO NOT INFLUENCE CREATININE-CLEARANCE, INULIN-CLEARANCE OR PAH-CLEARANCE IN HEALTHY MALE-VOLUNTEERS

The effects of the non-steroidal anti-inflammatory drug diclofenac and the pyrazolone derivative dipyrone on renal function were compared wi th those of placebo in 12 healthy male volunteers in a randomized, con trolled, triple-crossover study with a wash-out period of 4 days betwe en each of the 3 trial periods (dipyrone, diclofenac and placebo) whic h lasted three days each. The volunteers received dipyrone(1 g, 3 time s/day for 2 days, followed by twice 1 g on the main trial day, which w as day 3 of each study period) or diclofenac (50 mg, 3 times/day for 2 days, followed by twice 50 mg on the main trial day) or placebo orall y. Standardized meals (50 mEq sodium per day) were given from one week before the start until the end of the study and on the main trial day s a protein-rich lunch (2 g protein/kg body weight) was taken. Renal f unction was assessed in each study period by measurement of creatinine -clearance, inulin-clearance and p-aminohippurate (PAH)-clearance to c haracterize glomerular filtration rate and renal plasma flow. High pro tein intake induced glomerular hyperfiltration (increased creatinine-c learance, inulin-clearance and PAH-clearance) in all 3 study periods ( dipyrone, diclofenac, placebo). Dipyrone and diclofenac had no effect on renal clearance of creatinine, inulin or PAH in comparison to place bo. These results show that dipyrone and diclofenac at therapeutic dos ages over 3 days do not decrease glomerular filtration and renal plasm a flow in healthy individuals. Furthermore, it is unlikely that prostg landins play a major role in protein-induced glomerular hyperfiltratio n.