MACROPHAGE RECOGNITION OF LDL MODIFIED BY LEVUGLANDIN E(2), AN OXIDATION-PRODUCT OF ARACHIDONIC-ACID

Authors
HOPPE G SUBBANAGOUNDER G ONEIL J SALOMON RG HOFF HF
Citation
G. Hoppe et al., MACROPHAGE RECOGNITION OF LDL MODIFIED BY LEVUGLANDIN E(2), AN OXIDATION-PRODUCT OF ARACHIDONIC-ACID, Biochimica et biophysica acta, L. Lipids and lipid metabolism, 1344(1), 1997, pp. 1-5
Citations number
30
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta, L. Lipids and lipid metabolism → ACNP
ISSN journal
00052760
Volume
1344
Issue
1
Year of publication
1997
Pages
1 - 5
Database
ISI
SICI code
0005-2760(1997)1344:1<1:MROLMB>2.0.ZU;2-P
Abstract
Levuglandin (LG) E(2), a secoprostanoic acid levulinaldehyde derivativ e, is a product of free radical oxidation that forms covalent adducts with lysyl residues on proteins. Treatment of LDL with LGE(2) leads to uptake and degradation by mouse peritoneal macrophages. Oxidized LDL, but not acetyl LDL efficiently competed for binding and uptake of LGE (2)-modified I-125-LDL. This result suggests that LGE(2)-modified LDL was recognized by a class of scavenger receptor that demonstrated liga nd specificity for oxidized LDL but not for acetyl LDL.