VACCINATION OF SHEEP AGAINST HEMONCHOSIS WITH H11, A GUT MEMBRANE-DERIVED PROTECTIVE ANTIGEN FROM THE ADULT PARASITE - PREVENTION OF THE PERIPARTURIENT RISE AND COLOSTRAL TRANSFER OF PROTECTIVE IMMUNITY

Authors
ANDREWS SJ HOLE NJK MUNN EA ROLPH TP
Citation
Sj. Andrews et al., VACCINATION OF SHEEP AGAINST HEMONCHOSIS WITH H11, A GUT MEMBRANE-DERIVED PROTECTIVE ANTIGEN FROM THE ADULT PARASITE - PREVENTION OF THE PERIPARTURIENT RISE AND COLOSTRAL TRANSFER OF PROTECTIVE IMMUNITY, International journal for parasitology, 25(7), 1995, pp. 839-846
Citations number
26
Categorie Soggetti
Parasitiology
Journal title
International journal for parasitology → ACNP
ISSN journal
00207519
Volume
25
Issue
7
Year of publication
1995
Pages
839 - 846
Database
ISI
SICI code
0020-7519(1995)25:7<839:VOSAHW>2.0.ZU;2-P
Abstract
Pregnant ewes were immunised with a fraction highly enriched in the me mbrane glycoprotein antigen H11, isolated from the intestinal brush bo rder of adult Haemonchus contortus. Immunity induced by immunisation w as able to abolish almost completely (98-99%) the worm egg output from pregnant ewes challenged with ca. 10,000 infective larvae of H. conto rtus during the last trimester. Furthermore, lambs born and reared on vaccinated ewes had substantial antibody levels to H11 derived from ma ternal transfer. This antibody conferred moderate protection against a bolus challenge of ca. 3000 infective larvae of H. contortus in 5-wee k-old lambs.