CONTRIBUTIONS OF MEMORY B-CELLS TO SECONDARY IMMUNE-RESPONSE

Authors
Citation
Sg. Guan et As. Qi, CONTRIBUTIONS OF MEMORY B-CELLS TO SECONDARY IMMUNE-RESPONSE, Bulletin of mathematical biology, 57(5), 1995, pp. 713-731
Citations number
47
Categorie Soggetti
Mathematical Methods, Biology & Medicine","Biology Miscellaneous","Mathematics, Miscellaneous
ISSN journal
00928240
Volume
57
Issue
5
Year of publication
1995
Pages
713 - 731
Database
ISI
SICI code
0092-8240(1995)57:5<713:COMBTS>2.0.ZU;2-1
Abstract
The secondary immune response is one of the most important features of immune systems. During the secondary immune response, the immune syst em can eliminate the antigen, which has been encountered by the indivi dual during the primary invasion, more rapidly and efficiently. Both T and B memory cells contribute to the secondary response. In this pape r, we only concentrate on the functions of memory B cells. We explore a model describing the memory contributed by the specific long-lived c lone which is maintained by continued stimulation with a small amount of antigens sequestered on the surfaces of the follicular dendritic ce lls (FDC). The behavior of the secondary response provided by the mode l can be compared with experimental observations. The model shows that memory B cells indeed play an important role in the secondary respons e. It is found that a single memory cell in a long-lived clone may not be long-lived. In the present note, the influences of relevant parame ters on the secondary response are also explored.