We explore the influence of three-particle interactions, in either the
initial or final state, on the collision rate in a high temperature p
lasma, and on the rate of quark and anti-quark pair (flavor) productio
n. When the interactions are taken to be screened at the Debye wave nu
mber q(D) approximate to T, three-particle interactions contribute sig
nificantly to the collision rate, but only marginally enhance flavor p
roduction over that from two-particle interactions. The magnitudes of
the rates are, however, sensitive to the infra-red thresholds, which e
mphasizes the need for a reliable analysis of this issue. Our results
also highlight the importance of treating many-particle processes adeq
uately in the space-time evolution of quarks and gluons produced in ul
trarelativistic heavy-ion collisions.