AUTOANTIBODIES AGAINST BETA-CRYSTALLINS INDUCE LENS EPITHELIAL-CELL DAMAGE AND CATARACT FORMATION IN MICE

Authors
SINGH DP GURU SC KIKUCHI T ABE T SHINOHARA T
Citation
Dp. Singh et al., AUTOANTIBODIES AGAINST BETA-CRYSTALLINS INDUCE LENS EPITHELIAL-CELL DAMAGE AND CATARACT FORMATION IN MICE, The Journal of immunology, 155(2), 1995, pp. 993-999
Citations number
39
Categorie Soggetti
Immunology
Journal title
The Journal of immunology
ISSN journal
00221767 → ACNP
Volume
155
Issue
2
Year of publication
1995
Pages
993 - 999
Database
ISI
SICI code
0022-1767(1995)155:2<993:AABILE>2.0.ZU;2-W
Abstract
One-year-old B6C3/f mice, injected with beta-crystallins emulsified wi th CFA, developed lens epithelial cell damage. Both serum transfer and mAb transfer studies clearly established that the autoimmune insult i s induced by humoral immunity. Older mice were more susceptible to aut oimmune insult than younger animals. Lens epithelial cell damage invar iably proceeded to cortical and posterior subcapsular cataract formati on. This mouse model of experimental autoimmune cataract formation wil l facilitate the exploration of the relation between immune phenomena and human age-related cataract.