M. Freiregarabal et al., EFFECTS OF BUSPIRONE ON THE IMMUNE-RESPONSE TO STRESS IN MICE, Pharmacology, biochemistry and behavior, 51(4), 1995, pp. 821-825
Several experiments were conducted to evaluate the effects of buspiron
e, a selective 5-hydroxytryptamine-1A (5-HT1A) anxiolytic, on the immu
ne system of mice exposed to a chronic auditory stressor. Daily inject
ion with 0.5 and 1 mg/kg (intraperitoneally) of buspirone resulted in
a dose-dependent reduction in the stress-induced suppression of the na
tural killer (NK) cell activity and the in vitro and in vivo activity
of phagocytosis. Higher doses of buspirone (2.0 mg/kg) showed less rob
ust immunoenhancing effects in stressed mice, and caused a significant
suppression of these immune parameters in unstressed mice.