EFFECTS OF BUSPIRONE ON THE IMMUNE-RESPONSE TO STRESS IN MICE

Citation
M. Freiregarabal et al., EFFECTS OF BUSPIRONE ON THE IMMUNE-RESPONSE TO STRESS IN MICE, Pharmacology, biochemistry and behavior, 51(4), 1995, pp. 821-825
Citations number
39
Categorie Soggetti
Pharmacology & Pharmacy","Pharmacology & Pharmacy
ISSN journal
00913057
Volume
51
Issue
4
Year of publication
1995
Pages
821 - 825
Database
ISI
SICI code
0091-3057(1995)51:4<821:EOBOTI>2.0.ZU;2-G
Abstract
Several experiments were conducted to evaluate the effects of buspiron e, a selective 5-hydroxytryptamine-1A (5-HT1A) anxiolytic, on the immu ne system of mice exposed to a chronic auditory stressor. Daily inject ion with 0.5 and 1 mg/kg (intraperitoneally) of buspirone resulted in a dose-dependent reduction in the stress-induced suppression of the na tural killer (NK) cell activity and the in vitro and in vivo activity of phagocytosis. Higher doses of buspirone (2.0 mg/kg) showed less rob ust immunoenhancing effects in stressed mice, and caused a significant suppression of these immune parameters in unstressed mice.