BSH DISTRIBUTIONS IN THE CANINE HEAD AND A HUMAN PATIENT USING B-11 MRI

A 3D projection reconstruction (3DPR) method was used to obtain in viv o B-11 images in a large canine brain tumor model and in a human infus ed with borocaptate sodium (BSH). Studies were performed in dogs with and without gliosarcomas implanted and grown to a size of 2-3 cm. The 3BDPR method demonstrates a signal-to-noise ratio (SNR) that allows qu alitative kinetic studies of the boron compound in normal and tumor ti ssue of the head, The measurements indicate initial uptake of the BSH compound in tumor to be less than that in muscle with no uptake in nor mal brain tissue. Moreover, uptake of BSH in tissue was found to lag t he boron concentration in blood with delays that depend on tissue type , In addition, the first human boron images were obtained on a patient who underwent surgical resection and volumetric debulking of a large (7 cm) glioblastoma multiforme, BSH was readily taken up in residual t umor tissue, while diffusion into the resection volume was slower.