M. Marinozzi et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF 6-CARBOXY-3,4-METHANOPROLINES,NEW RIGID GLUTAMATE ANALOGS, Il Farmaco, 50(5), 1995, pp. 327-331
6-Carboxy-3,4-methanoprolines were prepared by reacting ethyl diazoace
tate with the suitable 3,4-didehydroproline derivative in the presence
of rhodium(II)acetate dimer as catalyst. The affinities of the title
compounds for displacement of receptor binding to ionotropic and metab
otropic (mGluR1 alpha) glutamate receptors were also determined.