SYNTHESIS AND BIOLOGICAL EVALUATION OF 6-CARBOXY-3,4-METHANOPROLINES,NEW RIGID GLUTAMATE ANALOGS

Citation
M. Marinozzi et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF 6-CARBOXY-3,4-METHANOPROLINES,NEW RIGID GLUTAMATE ANALOGS, Il Farmaco, 50(5), 1995, pp. 327-331
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
ISSN journal
0014827X
Volume
50
Issue
5
Year of publication
1995
Pages
327 - 331
Database
ISI
SICI code
0014-827X(1995)50:5<327:SABEO6>2.0.ZU;2-R
Abstract
6-Carboxy-3,4-methanoprolines were prepared by reacting ethyl diazoace tate with the suitable 3,4-didehydroproline derivative in the presence of rhodium(II)acetate dimer as catalyst. The affinities of the title compounds for displacement of receptor binding to ionotropic and metab otropic (mGluR1 alpha) glutamate receptors were also determined.