THE ANTITUMOR-ACTIVITY OF THE DNA FRACTION FROM MYCOBACTERIUM-BOVIS BCG (MY-1) FOR GLIOBLASTOMA

The antitumor activity of the DNA fraction extracted from Mycobacteriu m bovis BCG (MY-1) for glioblastoma was investigated in the experiment ally produced brain tumor in rats. The tumor-bearing rats were given i ntralesional injection of 1 mg of MY-1 twice a week for three weeks, a nd were sacrificed for comparison with those of control rats. The main macroscopic features of the tumors treated with serial injections of MY 1 were cystic and destructive structures, which were histologically characterized by multiple microcysts containing macrophages. Furtherm ore, infiltration of leukocytes as well as the perivascular cuffing in the marginal area was observed. These findings suggested that the ser ial injections of MY-1 into the brain tumor have the therapeutic poten tial for glioblastoma.