PLATELET-AGGREGATION IN IGE-MEDIATED ALLERGY WITH ELEVATED SOLUBLE FC(EPSILON)RII CD23 LEVEL/

In 25 house dust mite-sensitive patients with perennial allergic rhini tis, an analysis of platelet aggregation tests (dual-channel aggregome ter, Chronolog Corp, 345 model) induced by adenosine diphosphate (ADP) was carried out. The levels of total serum IgE specific antibodies ag ainst Dermatophagoides pteronyssinus and the soluble form of the low a ffinity IgE receptor (sFc(epsilon)RII/sCD23) were estimated as well. T he study was carried out in a dynamic state, before and after 2 years of treatment with specific immunotherapy. We observed a significantly diminished platelet aggregation response, which partially improved aft er treatment. The results of this study suggest that platelet hyporesp onsiveness might be involved in the pathogenesis of house dust mite hy persensitivity.