ANTIBODIES - PRODUCTION, FUNCTIONS AND APPLICATIONS IN BIOSENSORS

The antibody-antigen interaction is characterised by high affinity and high specificity, which makes it an excellent candidate as an analyti cal tool for selective and sensitive determinations. This biochemical interaction is being increasingly detected by solid-state physical tra nsducers, in devices which are termed 'biosensors'. The structure of t he antibody molecule is central to its binding function. In addition, several techniques are available by which antibodies may be produced. An appreciation of both of these areas is essential in developing an i mmunosensor. The choice of the appropriate transducer is also importan t, and this short article also highlights some recent applications inv olving the use of electrochemical, optical, surface acoustic wave and semiconductor transducers.