Purpose: To assess the optimum probe design and treatment parameters f
or transscleral diode laser retinopexy. Methods: Transscleral diode ph
otocoagulation was performed on the eyes of Dutch-belted rabbits using
three different transscleral probes: a straight, 400-mu m diameter pr
obe; a prism-tipped 400-mu m diameter probe; and a prism-tipped 900-mu
m diameter probe. Results: Transscleral diode photocoagulation with a
ll three probe types was an effective method of ablating the retina an
d creating chorioretinal adhesions. Both the burn diameter and the mea
n radiant output energy requirement increased as the burn duration and
probe aperture diameter was increased. Explosive retinal holes were e
ncountered in 12% of the burns created with the straight probe. The us
e of the prism-tipped probes significantly reduced the incidence of re
tinal holes to <4% (P < 0.005). Histopathologically, all burns were gr
ade III in intensity with severe choroidal injury. In many of the burn
s, there was histopathologic evidence of thermal injury to the inner s
clera. The frequency of these inner scleral changes was reduced with a
long burn duration (5 seconds) Conclusion: This study confirms that d
iode transscleral photocoagulation is a feasible method of thermal ret
inopexy. The use of the prism-tipped probes and long duration burns re
sulted in the fewest adverse reactions.