IONOPHORETIC PROPERTIES OF THE NON-SULFONYLUREA HYPOGLYCEMIC AGENTS A-4166 AND KAD-1229

Authors
BAKKALINADI A MALAISSELAGAE F MALAISSE WJ
Citation
A. Bakkalinadi et al., IONOPHORETIC PROPERTIES OF THE NON-SULFONYLUREA HYPOGLYCEMIC AGENTS A-4166 AND KAD-1229, Research communications in molecular pathology and pharmacology, 88(3), 1995, pp. 339-347
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Pathology,Biology
Journal title
Research communications in molecular pathology and pharmacology → ACNP
ISSN journal
10780297
Volume
88
Issue
3
Year of publication
1995
Pages
339 - 347
Database
ISI
SICI code
1078-0297(1995)88:3<339:IPOTNH>2.0.ZU;2-I
Abstract
The non-sulphonylurea hypoglycaemic agents A-4166 and KAD-1229 were bo th found to cause Ca-45 or Na-22 translocation from an aqueous medium into an organic immiscible phase. This ionophoretic effect was more ma rked with A-4166 than KAD-1229, in mirror image of their insulinotropi c potency. Such a dissociated behaviour argues against the view that t he ionophoretic properties of these agents represent a major determina nt of their insulinotropic action.