The purpose of this study was to find out possible differences in pren
atal diagnosis (PD) by amniocentesis or chorionic villus sampling and
ultrasound examination before 16 weeks' gestation (early ultrasound ex
amination, EUE), according to area of residence and level of education
of the mothers. Data come from a multicentre study in Italy involving
43 maternity hospitals (Mercurio project) and were collected through
structured interviews a few days after delivery. Study subjects were 1
541 mothers of single non-malformed infants born between April 1992 an
d March 1994. Overall, the incidence of PD and EUE was 5.8 and 80 per
cent, respectively. After adjustment for maternal age and other possib
le confounders, the odds ratios for PD were 2.19 (95 per cent confiden
ce interval (CI)=1.26-3.81) when women residing in the northern region
s were compared with those residing in the southern regions, and 2.06
(95 per cent CI=1.12-3.79) and 4.08 (95 per cent CI=1.97-8.42) when wo
men with medium and high levels of education were compared with those
with low level. For EUE, the odds ratios were 1.77 (95 per cent CI=1.3
2-2.36) and 2.88 (95 per cent CI=1.56-5.29) when comparing women with
medium and high levels of education with those with low level. No rela
tionship was found between area of residence and EUE. These geographic
al and social inequalities in prenatal care in Italy should be taken i
nto account for the organization, delivery, and evaluation of pregnanc
y services in the coming years.