FOLLOW-UP OF DIFFERENTIATED THYROID-CARCI NOMA BY (99)MTC-MIBI

Aim: The aim of the study has been the examination of the diagnostic v alue of Tc-99m-MIBI scintigraphy for the detection of local tumor or m etastases following total thyroidectomy and I-131 ablation therapy in differentiated thyroid carcinoma. Methods: MIBI-scintigraphy has been indicated in 85 patients because of ascending thyroglobulin values or suspected local recurrencies by ultrasonography. The results have been compared to cytology or histology or ultrasonography, computed tomogr aphy, X-ray and radioiodine scanning. Results: MIBI scintigraphy was f ound positive in 32 of 40 metastases. Only 18 metastases have been see n by radioiodine. MIBI scintigraphy was most effective in detecting lo cal tumor recurrencies and lymph node metastases (94%). The specifity of MIBI and radioiodine was similar (100%). In inflammatory enlarged l ymph nodes no MIBI uptake was found, so it is possible to differentiat e reactive lymph node enlargement from metastatic disease. Conclusion: In conclusion scintigraphy with Tc-99m-MiBI is advisable in suspected local recurrencies and negative radioiodine scan. It is favourable th at withdrawing TSH-suppressive hormone medication is not necessary.