5-HYDROXY-3-VINYL-2(5H)-FURANONE - A NEW INHIBITOR OF HUMAN SYNOVIAL PHOSPHOLIPASE A(2) AND PLATELET-AGGREGATION FROM FERMENTATIONS OF A CALYPTELLA SPECIES (BASIDIOMYCETES)

Authors
LORENZEN K ANKE T KONETSCHNYRAPP S SCHEUER W
Citation
K. Lorenzen et al., 5-HYDROXY-3-VINYL-2(5H)-FURANONE - A NEW INHIBITOR OF HUMAN SYNOVIAL PHOSPHOLIPASE A(2) AND PLATELET-AGGREGATION FROM FERMENTATIONS OF A CALYPTELLA SPECIES (BASIDIOMYCETES), Zeitschrift fur Naturforschung. C, A journal of biosciences, 50(5-6), 1995, pp. 403-409
Citations number
18
Categorie Soggetti
Biology
Journal title
Zeitschrift fur Naturforschung. C, A journal of biosciences → ACNP
ISSN journal
09395075
Volume
50
Issue
5-6
Year of publication
1995
Pages
403 - 409
Database
ISI
SICI code
0939-5075(1995)50:5-6<403:5-ANIO>2.0.ZU;2-A
Abstract
5-Hydroxy-3-vinyl-2(SH)-furanone, a potent and selective inhibitor of human synovial phospholipase A(2) was isolated from fermentations of a Calyptella species. Its structure as identified by spectroscopic meth ods is identical to PA 147, an antibiotic previously isolated from a s treptomycete. 5-hydroxy-3-vinyl-2(5H)-furanone inhibits the aggregatio n of human and bovine platelets stimulated by different inducers and e xhibits weak antimicrobial activities.