PRIMARY NON-HODGKINS-LYMPHOMA OF THE VAGINA - CASE-REPORT AND REVIEW OF THE LITERATURE

The genital tract as primary site of malignant non-Hodgkin's lymphoma in women is extremely rare, whereas secondary involvement in advanced disease is found in about 40% of cases. In this report a patient is pr esented who had a primary vaginal non-Hodgkin's lymphoma of the centro blastic type according to the Kiel classification, with an excellent r esponse to cytotoxic chemotherapy (CHOP) and event-free disease for 3 years. A review of the literature shows that favorable prognosis of lo calized disease seems to be a common experience. Primary involvement o f the vagina can be successfully treated by pelvic irradiation, but in young women cytotoxic chemotherapy should be considered to preserve f ertility.