Citation
Cp. Jain et Sp. Vyas, PREPARATION AND CHARACTERIZATION OF NIOSOMES CONTAINING RIFAMPICIN FOR LUNG TARGETING, Journal of microencapsulation, 12(4), 1995, pp. 401-407
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Applied","Engineering, Chemical
Journal title
ISSN journal
02652048
Volume
12
Issue
4
Year of publication
1995
Pages
401 - 407
Database
ISI
SICI code
0265-2048(1995)12:4<401:PACONC>2.0.ZU;2-7
Abstract
Niosomes (non-ionic, surfactant-based vesicles) containing rifampicin
of 8-15 mu m in diameter were prepared using Span-85 and cholesterol i
n various molar fractions. The process variables that could affect the
physical characteristics of niosomes and in vitro release of the drug
from the niosomes were studied and optimized. In vivo distribution st
udies of the prepared niosomes found that 65% of the drug could be loc
alized in the lungs by controlling the niosome size.