KEYHOLE LIMPET HEMOCYANIN CONTAINS GAL(BETA-1-3)-GALNAC DETERMINANTS THAT ARE CROSS-REACTIVE WITH THE T-ANTIGEN

Authors
WIRGUIN I SUTURKOVAMILOSEVIC L BRIANI C LATOV N
Citation
I. Wirguin et al., KEYHOLE LIMPET HEMOCYANIN CONTAINS GAL(BETA-1-3)-GALNAC DETERMINANTS THAT ARE CROSS-REACTIVE WITH THE T-ANTIGEN, Cancer immunology and immunotherapy, 40(5), 1995, pp. 307-310
Citations number
18
Categorie Soggetti
Immunology,Oncology
Journal title
Cancer immunology and immunotherapy → ACNP
ISSN journal
03407004
Volume
40
Issue
5
Year of publication
1995
Pages
307 - 310
Database
ISI
SICI code
0340-7004(1995)40:5<307:KLHCGD>2.0.ZU;2-G
Abstract
Keyhole limpet hemocyanin (KLH) is widely used as a carrier molecule t o enhance immune responses to administered antigens, and for immunothe rapy of bladder and renal carcinoma. In the present study we show, usi ng lectin and antibody binding studies, that native KLH contains Gal(b eta 1-3)GalNAc-bearing oligosaccharides, and that immunization with KL H in Lewis rats induces the production of anti-Gal(beta 1-3)GalNAc ant ibodies. This might explain the beneficial effect of KLH in bladder ca ncers that express crossreactive Gal(beta 1-3)GalNAc determinants or t he T antigen.