INDIRECT GENE DIAGNOSES FOR COMPLEX (MULTIFACTORIAL) DISEASES - A REVIEW

Authors
EPPLEN JT BUITKAMP J BOCKER T EPPLEN C
Citation
Jt. Epplen et al., INDIRECT GENE DIAGNOSES FOR COMPLEX (MULTIFACTORIAL) DISEASES - A REVIEW, Gene, 159(1), 1995, pp. 49-55
Citations number
48
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
159
Issue
1
Year of publication
1995
Pages
49 - 55
Database
ISI
SICI code
0378-1119(1995)159:1<49:IGDFC(>2.0.ZU;2-K
Abstract
The analysis of multifactorial diseases requires the efficient investi gation of large numbers of (gene) loci and patient (family) samples. S ince simple repetitive DNA markers are dispersed all over the chromoso mes; molecular techniques employing these tools render most convention al screening procedures obsolete. Examples of tumors, autoimmune disea ses and infections are presented to validate concepts of indirect gene diagnoses via simple, tandemly arranged, repetitive DNA sequences. Th e salient advantages of microsatellite technologies vs. those of multi locus DNA fingerprinting are weighed.