We investigated, by using simulations, possible mechanisms responsible
for the errors in the direction of arm movements exhibited by deaffer
ented patients. Two aspects of altered feedforward control were evalua
ted: the inability to sense initial conditions and the degradation of
an internal model. A simulation which assumed no compensation for vari
ations in initial arm configuration failed to reproduce the characteri
stic pattern of errors. In contrast, a simulation that assumed random
variability in the generation of joint torque resulted in a distributi
on of handpaths which resembled some aspects of the pattern of errors
exhibited by deafferented patients.