Tumors of the parapharyngeal space, although mostly benign in their hi
stopathology, present a challenge to the surgeon due to the limited ac
cess. Multiple approaches have been described in the literature for th
e extirpation of these tumors. The usual anatomic division of the para
pharyngeal space into prestyloid and poststyloid spaces does not help
the clinician determine which approach to use for a specific tumor. We
have reviewed out 10-year experience at the University of Zurich. The
usual presentation of the patients and the histopathologic characteri
stics of their tumors are compared. The radiological evaluation of the
se patients, their perioperative course, and complications are analyze
d. The different surgical techniques used to treat the 72 patients in
our series are described, with a special emphasis on the infratemporal
fossa approach. Furthermore, a clinical division of the parapharyngea
l space in the superior-inferior axis is estabilished. The usefulness
of this classification in helping the surgeon to decide which surgical
approach is the most suitable for a particular lesion is discussed.