A COMPARISON OF THE FUNCTIONAL-ACTIVITY OF MONOCLONAL AND POLYCLONAL RH ANTIBODIES

Authors
DOWNING I FRASER RH TEMPLETON JG
Citation
I. Downing et al., A COMPARISON OF THE FUNCTIONAL-ACTIVITY OF MONOCLONAL AND POLYCLONAL RH ANTIBODIES, Transfusion clinique et biologique, 3(6), 1996, pp. 479-481
Citations number
6
Categorie Soggetti
Hematology,Immunology
Journal title
Transfusion clinique et biologique → ACNP
ISSN journal
12467820
Volume
3
Issue
6
Year of publication
1996
Pages
479 - 481
Database
ISI
SICI code
1246-7820(1996)3:6<479:ACOTFO>2.0.ZU;2-C
Abstract
The functional activity of monoclonal anti-Ds has been compared with t hat of non-D monoclonal antibodies. Approximately 50% of anti-Ds were more active than a positive control while more than 75% of non-D antib odies failed to reach 10% activity of the positive control. These figu res do not correlate with the IgG bound per red cell which, however, d oes correlate closely with the antigen site density as would be expect ed.