Leptospirosis has been reported in llamas living in North America. LIa
mas in some locations are routinely vaccinated against leptospirosis i
n an attempt to prevent the disease. In order to determine if llamas r
espond to a leptospirosis vaccine, 14 llamas were immunized twice at 2
week intervals with a commercially available five-way leptospirosis v
accine. Blood was then collected for serum titer evaluation using a mi
croagglutination technique for 5 months. Serologic response to the vac
cine was low and of short duration to all five serovars, regardless of
prevaccination titer. By 12 weeks postvaccination, only animals with
serum titers greater than or equal to 1:200 to Leptospira pomona preva
ccination still had serum titers greater than or equal to 1:200. Seven
references are cited.