K. Ohnishi et al., AGE-RELATED DECREASE OF NERVE GROWTH FACTOR-LIKE IMMUNOREACTIVITY IN THE BASAL FOREBRAIN OF SENESCENCE-ACCELERATED MICE, Acta Neuropathologica, 90(1), 1995, pp. 11-16
The senescence-accelerated mouse P10 (SAMP10) is a murine model of acc
elerated senescence characterized by the deterioration of learning and
memory with advancing age. In the present study, we examined the dist
ribution of nerve growth factor (NGF) immunohistochemically in SAMP10
mice and its control strain, SAMR1. In both strains, NGF-like immunore
activity (NGF-IR) was observed in neurons throughout the entire forebr
ain and in glial cells in a particular location. In aged SAMP10 mice,
each layer of the cerebral cortex retained its NGF-IR, although the th
ickness of the cortical mantle was markedly decreased in comparison wi
th younger animals. There was an age-related decline in NGF-IR in the
substantia innominata of SAMP10 mice at the age of 10 months, when com
pared to 2-month-old SAMP10. These results indicate age-related decrea
se of NGF in the basal forebrain in SAMP10 mice.