PHYSICAL ASPECTS OF DEXIBUPROFEN AND RACEMIC IBUPROFEN

This article presents a comparative study of ibuprofen materials in th eir solid slate. Ibuprofen crystallizes into two different structures for the S(+) enantiomer (dexibuprofen) and racemic ibuprofen. The crys tal structure of ibuprofen, its optical absorption and photoluminescen ce, and the thermodynamic results (melting point and heat of fusion) a re discussed. From these physicochemical properties, the authors concl ude that dexibuprofen, which is the most active species pharmaceutical ly, and racemic ibuprofen are inherently different solid-state materia ls.